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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Cancer Cell. 2012 Jul 10;22(1):131–138. doi: 10.1016/j.ccr.2012.05.036

Figure 2. NSCs from the lv-SVZ and TVZ are molecularly-distinct progenitor populations with unique cell-autonomous responses to glioma-causing genetic mutations.

Figure 2

(A) SAM separates lv-SVZ and TVZ NSCs with the expression level represented as standardized values from −1.6 (blue, <1-fold change) to 1.6 (red, >1-fold change). No change (0 value) is denoted by grey. (B) Validation of select differentially-expressed transcripts by qRT-PCR with fold changes (FC) and p values (p) shown. (C) Increased neurosphere diameters were observed in NSCs from both the lv-SVZ and TVZ following p53. Increased neurosphere diameters were found only in lv-SVZ NSCs following Pten loss. Increased neurosphere diameters were observed only in TVZ NSCs following KIAA1549:BRAF expression (RT-PCR). Values denote the mean ± SEM. p*<0.01, p**<0.001, p***<0.0001. See also Figure S1.