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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Cancer Cell. 2012 Jul 10;22(1):131–138. doi: 10.1016/j.ccr.2012.05.036

Figure 3. TVZ NSCs are preferentially sensitive to Nf1 loss.

Figure 3

(A) Increased optic nerve volume (white arrow) and abnormal cell clusters (black arrow) were observed in optic gliomas from 3-month-old Nf1+/− GFAP mice. (B) The potential cellular origins (lv-SVZ and TVZ) of optic gliomas in Nf1 mutant mice are illustrated. LV: lateral ventricle, red: lateral geniculate nucleus, green: optic tract, TV: third ventricle, yellow: optic chiasm. (C) Increased TVZ neurosphere proliferation was seen following Nf1 loss, with little effect on lv-SVZ NSCs. (D) 3-fold more Olig2+ cells were found in the TVZ of Nf1BLBP mice (p=0.0004), but not in the lv-SVZ (p=0.0836), compared to controls. (E) Increased numbers of GFAP+ cells were found in the TVZ, but not in the lv-SVZ, of Nf1BLBP mouse compared to controls. Values denote the mean ± SEM. See also Figure S2.