Table 2.

Logistic parameters and related variables for antibody producing CHO cells in fed-batch culture

Viable cell density			Product concentration
Parameter	Combs et al. (2011)	Huang et al. (2010)	Parameter	Combs et al. (2011)	Huang et al. (2010)
a1 (106 cells/mL)	67.6	48.9	b1 (g/L)	4.3	10.4
a2 (day−1)	0.16	0.07	b2	184.6	117.8
a3	236.8	53.6	b3 (day−1)	0.60	0.38
a4 (day−1)	0.65	0.55	Pmax (g/L)	4.1	9.8
tmax (day)	8.4	9.6	Avg. qP (pg/cell-day)	36.5	33.3
Xmax (106 cells/mL)	13.7	21.7	Max. qP (pg/cell-day)	47.6	54.4
μmax (day−1)	0.64	0.54
kdmax (day−1)	0.16	0.07

The associated time profiles of viable cell density and product concentration along with the logistic fits are shown in Figs. 3 and 4