Table 2.

Outcomes at 18 months, severe periventricular or intraventricular hemorrhage, PDA and surgical closure of PDA by exposure to antenatal steroids

Outcome	Antenatal steroids	Indomethacin n/N (%)	Placebo n/N (%)	Odds ratio (95% CI)†	P value for interaction
					Unadjusted	Adjusted for center/BW‡	Adjusted for other factors§
Death or impairment	Adequate	145/319 (45.5)	127/316 (40.2)	1.24 (0.90, 1.70)	0.13	0.10	0.15
	Inadequate	123/250 (49.2)	133/251 (53.0)	0.86 (0.61, 1.22)
Death	Adequate	60/332 (18.1)	45/331 (13.6)	1.40 (0.92, 2.14)	0.22	0.28	0.16
	Inadequate	64/258 (24.8)	66/261 (25.3)	0.97 (0.66, 1.45)
Cerebral palsy	Adequate	37/270 (13.7)	31/281 (11.0)	1.28 (0.77, 2.13)	0.23	0.23¶	0.27
	Inadequate	19/193 (9.8)	24/194 (12.4)	0.77 (0.41, 1.46)
Cognitive delay	Adequate	68/257 (26.5)	62/269 (23.0)	1.20 (0.81, 1.78)	0.34	0.25	0.26
	Inadequate	49/183 (26.8)	54/186 (29.0)	0.89 (0.57, 1.41)
Deafness	Adequate	7/264 (2.7)	5/276 (1.8)	1.48 (0.46, 4.72)	0.34	0.34¶	0.72
	Inadequate	3/188 (1.6)	5/188 (2.7)	0.59 (0.14, 2.52)
Blindness	Adequate	4/268 (1.5)	5/277 (1.8)	0.82 (0.22, 3.11)	0.30	0.29¶	0.53
	Inadequate	5/193 (2.6)	2/193 (1.0)	2.54 (0.49, 13.3)
Severe P/IVH	Adequate	21/321 (6.5)	28/322 (8.7)	0.73 (0.41, 1.32)	0.62	0.63	0.53
	Inadequate	31/245 (12.7)	47/243 (19.3)	0.60 (0.37, 0.99)
Patent ductus arteriosus (PDA)	Adequate	72/335 (21.5)	157/335 (46.9)	0.31 (0.22, 0.43)	0.89	0.99	0.78
	Inadequate	69/261 (26.4)	144/264 (54.5)	0.30 (0.21, 0.43)
Surgical closure of PDA	Adequate	21/335 (6.3)	40/335 (11.9)	0.49 (0.28, 0.86)	0.97	0.94¶	0.80
	Inadequate	18/261 (6.9)	34/264 (12.9)	0.50 (0.28, 0.91)

^†CI, Confidence interval.

^‡BW, Birth weight stratum.

^§In addition, adjusted for gestational age, gender, multiple births and mother’s education.

^¶Adjusted for birth weight stratum only.