Fig. 1.

Schematic representation of the spatial and temporal integration taking place in the nervous system. (a) Adapted from [7]: spatial scales necessary for multiscale modeling ranging from the molecular (nanometer scale) to the systems level (centimeter scale). (b) In parallel to spatial complexity, the nervous system exhibits temporal complexity, as events take place from the microsecond range to the minute and hour range. Determining the appropriate LOD (red line) both in terms of spatial and temporal accuracy allows for reasonable approximation, while covering a wide range of spatiotemporal scales.