Table 1.
Baseline participant characteristics of the five discovery cohorts in the meta-analysis of genome-wide association studies of coronary artery calcification
| Characteristic Mean (SD) or N (Percent) |
AGES-Reykjavik N=3,177 |
FHS N=3,207 |
GENOA N=629 |
RS I N=1,720 |
RS II N=1,228 |
|---|---|---|---|---|---|
| Years of CAC measurements | 2002–2006 | 2002–2005 | 2000–2004 | 1997–2000 | 2003–2006 |
| Scanner Type | MDCT, 4 Detector | MDCT, 8 Detector | EBCT (C-150) | EBCT (C-150) | MDCT, 16 or 64 Detector |
| Age, years | 76.4 (5.5) | 52.2(11.6) | 58.0 (9.8) | 70.7 (5.5) | 67.2 (6.7) |
| Women, % | 58 | 49 | 58 | 54 | 53 |
| Mean CAC Score | 686 (1011) | 131 (432) | 191 (487) | 505 (969) | 312 (712) |
| Maximum CAC Score | 8,673 | 5,016 | 4,867 | 12,611 | 8,636 |
| Detectable CAC, % | 88.2 | 41.6 | 68.2 | 91.0 | 80.0 |
| CAC score >100, % | 66.7 | 19.0 | 28.3 | 54.4 | 40.5 |
| CAC score >300, % | 48.8 | 10.3 | 14.3 | 36.3 | 25.7 |
| Hypertension, % | 80.1 | 28.0 | 71.2 | 61.9% | 63.8 |
| Diabetes, % | 11.5 | 5.2 | 13.4 | 13.7 | 10.2 |
| Current cigarette smoker, % | 12.7 | 12.9 | 9.5 | 17.3 | 14.9 |
| Former cigarette smoker, % | 45.3 | 34.5 | 34.2 | 54.7 | 54.1 |
| Total cholesterol, mmol/L | 5.70 (1.17) | 5.08 (0.91) | 5.18 (0.88) | 5.83 (0.96) | 5.70 (0.98) |
| HDL cholesterol, mmol/L | 1.61 (0.47) | 1.40 (0.44) | 1.35 (0.41) | 1.40 (0.39) | 1.45 (0.38) |
| Triglyceride, mmol/L | 1.22 (0.67) | 1.44 (1.01) | 1.80 (1.19) | 1.54 (0.79) | NA |
| BMI, kg/m2 | 27.1 (4.4) | 27.7 (5.3) | 30.7 (6.3) | 27.0 (3.9) | 27.8 (4.9) |
| Waist circumference, cm | 101 (12) | 97 (16) | 101 (16) | 94 (11) | 94 (12) |
| Prevalent MI, % | 7.5 | 1.2 | 0 | 7.7 | 4.2 |
Abbreviations: CAC=coronary artery calcification AGES-Reykjavik=Age, Gene/Environment Susceptibility Study; BMI=body mass index; FHS=Framingham Heart Study; HDL=high density lipoprotein; GENOA=Genetic Epidemiology Network of Arteriopathy; RS=The Rotterdam Study; MDCT=multidetector computed tomography; EBCT=electron beam computed tomography; MI=myocardial infarction; NA=not available.