Table 3.

Association of top coronary artery calcification quantity SNPs in replication panel of three cohorts and combined with the discovery cohorts

SNP	Chr	Position	Closest Reference Gene†	Distance from Nearest Transcript††	Coded allele	Replication		Discovery + Replication*
						Beta (SE)	P	Beta (SE)	P
rs1333049	9	22,115,503	(CDKN2B)	116,191	C	0.147 (0.026)	1.41 × 10−8	0.199 (0.020)	3.33 × 10−24
rs9349379	6	13,011,943	PHACTR1	186,125	A	−0.187 (0.026)	1.22 × 10−12	−0.196 (0.020)	3.90 × 10−22
rs2026458	6	12,933,860	PHACTR1	108,042	T	0.082 (0.026)	1.73 × 10−3	0.115 (0.020)	8.10 × 10−9
rs3809346	13	109,758,944	COL4A2	1,313	A	0.064 (0.027)	1.79 × 10−2	0.102 (0.021)	8.64 × 10−7
rs6783981	3	169,010,823	SERPINI1	15,225	T	0.009 (0.026)	7.26 × 10−1	−0.054 (0.019)	5.85 × 10−3
rs17676451	12	94,899,916	HAL	8,644	A	−0.003 (0.036)	9.24 × 10−1	−0.084 (0.026)	1.12 × 10−3
rs6604023	1	91,717,485	(CDC7)	21,546	C	0.051 (0.036)	1.59 × 10−1	0.111 (0.027)	3.66 × 10−5
rs8001186	13	109,174,856	(IRS2)	29,328	T	−0.005 (0.028)	8.59 × 10−1	−0.068 (0.021)	1.37 × 10−3

^†Genes for SNPs that are outside the transcript boundary of the protein-coding gene are shown in parentheses [e.g., (CDKN2B)].

^††Distance in base pairs from nearest start or stop site for transcription.

^*Combined p-values in bold are below the genome-wide threshold; other combined p-values are not significant at a genome-wide level.