Table 1.

UICC TNM Staging for Gallbladder cancer (2009) [19]

Primary Tumour (T):
Tx	Primary tumour could not be assessed
T0	No evidence of primary tumour
Tis	Carcinoma in situ
T1	Tumour invades lamina propria or muscular layer
T1a	Tumour invades lamina propria
T1b	Tumour invades muscular layer
T2	Tumour invades perimuscular connective tissue; no extension beyond serosa or in to liver
T3	Tumour perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one another organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extra hepatic bile ducts
T4	Tumour invades main portal vein or hepatic artery or invades two or more extra hepatic organs or structures
Regional Lymph Nodes (N):
Nx	Regional Lymph Nodes cannot be assessed
N0	No Regional Lymph Node metastasis
N1	Metastases to nodes along the cystic duct, common bile duct, common hepatic artery, and portal vein
Distant Metastasis (M):
M0	No Distant Metastasis
M1	Distant Metastasis
Staging Gruops
Stage 0	Tis	N0	M0
Stage I	T1	N0	M0
Stage II	T2	N0	M0
Stage IIIA	T3	N0	M0
Stage IIIB	T1-3	N1	M0
Stage IVA	T4	Any N	M0
Stage IVB	Any T	Any N	M1