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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Pediatr Neurol. 2011 Dec;45(6):355–367. doi: 10.1016/j.pediatrneurol.2011.08.010

Figure 2.

Figure 2

The two best characterized subgroups of ISS-associated genes illustrated with the stages of central nervous system (CNS) development. Group A includes transcription factors essential to CNS dorsal-ventral differentiation (FOXG1), affecting neuroprogenitor cells broadly, with downstream effects on synapse function, as well as ARX, which is involved in ventral GABAergic interneuron differentiation, migration, and synaptogenesis. MEF2C is probably involved in this process as well. Group D genes (GRIN1, GRIN2A, MAGI2, SPTAN1, STXBP1) encode binding proteins or receptors with direct roles in presynaptic and/or postsynaptic development and function. 1 = Dorsal-ventral differentiation; 2 = Dorsal neuroprogenitor cell proliferation; 3 = Ventral neuroprogenitor cell proliferation; 4 = GABAergic interneuron migration; 5 = Intermediate progenitor cell proliferation; 6 = Glutaminergic neuron migration; 7 = Axonogenesis; 8 = Synaptogenesis; Red = primary role in developmental stage; Pink = Secondary effect on developmental stage; L = lateral ganglionic eminence; M/MGE = medial ganglionic eminence; MZ = marginal zone; CP = cortical plate; IZ = intermediate zone; SVZ = subventricular zone; VZ = ventricular zone