Table 1.
Intracellular thiol levels in HL60 cells treated with 300 μmol/L NOV-002
Time, h | GSH (μmol/L)/mg | GSSG, (μmol/L)/mg | Total, (μmol/L)/mg | GSH/GSSG |
---|---|---|---|---|
Control | 24.2 ± 7.7 | 0.78 ± 0.06 | 25.0 ± 7.8 | 31 ± 9.0 |
1 | 50.5 ± 3.2* | 2.52 ± 0.54* | 53.1 ± 3.8* | 20 ± 3.8* |
4 | 38.8 ± 6.2* | 1.50 ± 0.14* | 40.7 ± 6.6* | 25 ± 1.4 |
24 | 22.0 ± 1.5 | 0.89 ± 0.09 | 23.4 ± 1.4 | 25 ± 2.4 |
NOTE: The results are expressed as the mean ± SE from triplicate experiments.
P < 0.05.