Table 2.
Median, minimum, maximum, and the 95% CI of the median for amino acids in colon cancer patients and controls
| Colon cancer patients (n = 59) [μmol/l]a | Controls (n = 58) [μmol/l]a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median | Range | Median CI 95% | Median | Range | Median CI 95% | |||||
| Minimum | Maximum | Low | High | Minimum | Maximum | Low | High | |||
|
Glutamine (Gln) (CID 5961) |
0.72 | 0.27 | 1.62 | 0.72 | 0.72 | 0.69 | 0.42 | 1.86 | 0.69 | 0.69 |
|
Lysine (Lys)* (CID 5962) |
232.41 | 136.62 | 481.02 | 231.6 | 233.25 | 278.52 | 133.56 | 133.56 | 277.56 | 279.48 |
|
Hydroxyproline (OH-Prol) (CID 5810) |
365.85 | 222.81 | 731.04 | 364.95 | 366.78 | 405.99 | 232.65 | 954.00 | 405.15 | 406.8 |
|
Pipecolic acid (PiPA) (CID 849) |
94.32 | 64.62 | 228.27 | 228.27 | 94.53 | 99.78 | 61.59 | 178.02 | 99.54 | 100.05 |
|
Abscisic acid (Aba) (CID 5280896) |
6.90 | 2.25 | 21.24 | 6.87 | 6.93 | 7.20 | 3.09 | 14.67 | 7.17 | 7.23 |
|
Alaninea (Ala)** (CID 5950) |
238.95 | 124.08 | 408.24 | 238.32 | 239.55 | 282.66 | 174.18 | 453.96 | 281.67 | 283.62 |
|
Argininea (Arg) (CID 6322) |
71.52 | 38.79 | 129.27 | 71.34 | 71.70 | 77.58 | 36.45 | 139.08 | 77.43 | 77.76 |
|
Aspartic acida (Asp)* (CID 5960) |
328.26 | 89.07 | 1821.69 | 324.3 | 332.22 | 538.74 | 75.75 | 1300.23 | 534.75 | 542.76 |
|
Carnosin (Carn) (CID 439224) |
1.29 | 0.03 | 3.72 | 1.29 | 1.29 | 1.17 | 0.30 | 3.06 | 1.14 | 1.17 |
|
Citrullinea (Cit) (CID 9750) |
22.77 | 10.80 | 51.75 | 22.68 | 22.83 | 25.44 | 12.54 | 40.47 | 25.38 | 25.50 |
|
Glutamic acida (Glu) (CID 33032) |
129.99 | 86.82 | 187.38 | 129.75 | 130.23 | 127.32 | 77.25 | 207.66 | 126.99 | 127.65 |
|
Glycinea (Gly)*** (CID 750) |
151.35 | 87.51 | 269.13 | 151.08 | 151.62 | 180.96 | 107.64 | 359.16 | 180.06 | 181.89 |
|
Histidine (His)*** (CID 6274) |
79.80 | 39.30 | 221.19 | 79.62 | 80.01 | 96.15 | 62.01 | 200.91 | 95.91 | 96.39 |
|
Leucinea/Isoleucine (Leu/Ile)** (CID 6106/CID 6306) |
114.18 | 68.67 | 232.47 | 113.82 | 114.54 | 139.74 | 75.96 | 272.31 | 139.41 | 140.1 |
|
Methyl-Histidine (MeHis) (CID 64969) |
9.03 | 3.66 | 49.77 | 8.97 | 9.09 | 8.94 | 3.57 | 22.92 | 8.91 | 9.00 |
|
Methioninea (Met)* (CID 6137) |
14.58 | 2.97 | 78.60 | 14.55 | 14.64 | 16.92 | 9.87 | 35.28 | 16.86 | 16.98 |
|
Ornithinea (Orn) (CID 6262) |
53.43 | 31.83 | 88.08 | 53.34 | 53.55 | 55.65 | 26.49 | 108.36 | 55.53 | 55.77 |
|
Phenylalaninea (Phe) (CID 994) |
58.65 | 37.14 | 111.57 | 58.50 | 58.83 | 61.23 | 37.38 | 132.78 | 61.08 | 61.38 |
|
Proline (Pro) (CID 8988) |
186.15 | 98.13 | 408.87 | 185.52 | 186.78 | 178.92 | 112.38 | 520.41 | 178.35 | 179.52 |
|
Sarcosine (Sarc)* (CID 1088) |
85.20 | 55.44 | 178.29 | 84.99 | 85.38 | 99.90 | 51.09 | 215.07 | 99.51 | 100.32 |
|
Serine (Ser) (CID 5951) |
96.90 | 50.67 | 163.29 | 96.69 | 97.14 | 92.79 | 54.63 | 205.92 | 92.55 | 93.03 |
|
Taurine (Tau) (CID 1123) |
2.46 | 1.23 | 5.19 | 2.46 | 2.49 | 2.31 | 0.90 | 5.43 | 2.28 | 2.31 |
|
Threonine (Thr)** (CID 6288) |
11.73 | 6.09 | 22.68 | 11.7 | 11.76 | 14.01 | 7.35 | 25.65 | 13.98 | 14.04 |
|
Tryptophan (Trp) (CID 6305) |
7.65 | 3.57 | 21.21 | 7.62 | 7.65 | 7.68 | 3.09 | 17.28 | 7.65 | 7.68 |
|
Tyrosinea (Tyr)* (CID 6057) |
46.08 | 27.27 | 69.96 | 45.96 | 46.23 | 50.52 | 32.64 | 92.79 | 50.40 | 50.64 |
|
Valinea (Val)* (CID 6287) |
231.99 | 132.99 | 364.50 | 231.51 | 232.50 | 260.49 | 158.49 | 401.97 | 260.07 | 260.94 |
Significance of group differences is given by * for P < 0.05, ** for P < 0.01 and *** for P < 0.001 (Wilcoxon-test); Italics show significant deviation from normal distribution (Anderson–Darling-test, computed on the original data). Median, minimum, maximum, and the 95% CI of the median are computed on the bootstrapped data (B = 999). Concentrations are μmol/l for amino acids quantified via internal standard (marked by a) and relative for all others (cf. Brauer et al. 2011). Metabolites are identified by their PubChem Compound ID (CID)