Table 1.
Associations between F3 rs12029080 G-allele and incident venous thrombosis
| Design | Events, n |
Male, % |
Age*, yrs |
PE, % |
Idiopathic, % |
MAF | Beta coefficient (SE) |
Odd ratio (95% CI) | |
|---|---|---|---|---|---|---|---|---|---|
| HVH | CC | 656 | 0 | 64.7 | 48 | 59 | 0.304 | −0.073 (0.092) | 0.93 (0.8, 1.08) |
| EOVT | CC | 419 | 55 | 36.0 | 0 | 100 | 0.327 | 0.091 (0.089) | 1.10 (0.95, 1.27) |
| LITE (ARIC) | Cohort | 248 | 47 | 56.0 | 42 | 36 | 0.299 | 0.040 (0.097) | 1.04 (0.89, 1.22) |
| LITE (CHS) | Cohort | 119 | 43 | 73.0 | 30 | 39 | 0.317 | 0.199 (0.138) | 1.22 (0.97, 1.53) |
| MARTHA | CC | 1542 | 34 | 47.0 | 22 | 55 | 0.316 | 0.023 (0.060) | 1.02 (0.93, 1.13) |
| Mayo VTE | CC | 1503 | 50 | 54.9 | 50 | 43 | 0.299 | −0.068 (0.063) | 0.93 (0.84, 1.04) |
| RS-1 | Cohort | 177 | 43 | 69.5 | 44 | 53 | 0.291 | −0.108 (0.120) | 0.90 (0.74, 1.09) |
| RS-2 | Cohort | 19 | 63 | 66.3 | 42 | 53 | 0.286 | 0.161 (0.353) | 1.17 (0.66, 2.10) |
| WGHS | Cohort | 434 | 0 | 65.4 | 41 | 44 | 0.299 | 0.173 (0.076) | 1.19 (1.05, 1.35) |
|
| |||||||||
| Combined | 5117 | 34 | 54.1 | 35 | 53 | 0.299** | 0.026 (0.029)*** | 1.03 (0.89-1.08) | |
CI = confidence interval; MAF = minor allele frequency; SE = standard error. The Rotterdam Study analyzed 2 subcohorts separately: RS-1 and RS-2.
*
Age at the time of the event among case subjects.
**
Averaged.
***
Weighted by inverse of variance.