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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: Adv Mater. 2011 Aug 15;23(36):H217–H247. doi: 10.1002/adma.201102313

Figure 16.

Figure 16

Time course study of intracellular retention of fluorescent-labeled Tx in MCF-7 cells. Cells were treated with drug in solution (Tx-Sol) or unconjugated drug-loaded NPs (Tx-NPs) or Tf-conjugated NPs (Tx-NPs-Tf) (dose = 10 ng/mL) in the growth medium. Cells treated with Tx-Sol showed a decrease in green fluorescence intensity of the drug with incubation time whereas Tx-NPs and Tx-NPs-Tf demonstrated an increase, with Tf-conjugated NPs demonstrating the fluorescence of the drug lasting up to 8 days. N = nucleus. Reproduced with permission.[244] Copyright 2005, American Chemical Society.