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Targeting strategies to improve NP delivery throughout the tumor. I) Non-PEGylated NPs accumulate in the tumor site through the EPR effect. II) PEGylated NPs show enhanced accumulation in the tumor site through the EPR effect. III) Targeted NPs show better distribution throughout the tumor and higher cellular uptake. IV) Subcellular targeting increases NP delivery to the intracellular site of action of the drug.
