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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: Adv Mater. 2011 Aug 15;23(36):H217–H247. doi: 10.1002/adma.201102313

Figure 8.

Figure 8

In vivo MRI detection of labeled lymphocytes in a mouse tumor. a,b: Sequential MR images (3D-SPGR, voxel (60 μm)3) of the tumor in mice 48 h after injection of three million unlabeled lymphocytes (a) or the same number of magnetically labeled cells (b; iron load 1.3 pg/cell at the time of injection). Control tumors (a) give a homogeneous signal, whereas punctuate signal voids (white arrows) distributed throughout the tumor are observed in tumors of mice that received labeled lymphocytes (b). c,d: Zoom of the tumor image containing a signal void (d; labeled lymphocytes) or no signal void (c; control). Reproduced with permission.[175]