Table 1.

Previously Reported Loci Showing Associations with QTc Interval in the Phase 1 GWAS

Gene	GWAS SNP	Effect Size (β) in ms	95% Confidence Interval		GWAS p	Reported SNP	Effect Size (β) in ms	95% Confidence Interval		Reported p	Study Population	Distance from GWAS SNP (bp)	LD States
			Lower	Upper				Lower	Upper				r2	D′
NOS1AP	rs4657175	1.709	1.156	2.261	1.4 × 10−9	rs4657178	2.19	1.76	2.62	7 × 10−33	QTSCD	14,873	0.53	0.97
NDRG4-CNOT1	rs37060	1.52	0.957	2.084	1.3 × 10−7	rs37060	1.75	1.41	2.09	3 × 10−25	QTGEN	0	1	1
KCNQ1	rs16928297	1.105	0.5582	1.653	7.6 × 10−5	rs12296050	1.49	0.95	1.93	3 × 10−17	QTSCD	3,222	0.91	1
PLN	rs7764093	0.869	0.2894	1.449	0.00331	rs11970286	1.64	1.25	2.03	2 × 10−24	QTSCD	−11,930	0.57	0.96
SCN5A	rs2268755	0.805	0.2663	1.344	0.00341	rs12053903	1.23	0.88	1.57	1 × 10−14	QTGEN	91,477	0.597	0.79
KCNH2	rs2968854	1.632	0.416	2.848	0.00853	rs2968863	1.35	0.98	1.8	2 × 10−15	QTSCD	−14,697	0.55	0.74

The following abbreviations are used: GWAS, genome-wide association study, and LD, linkage disequilibrium.