Table 3.

p Values and Association Parameters for Top SNPs in Genome-wide Association Study for Prothrombin Time by INR

Region	Top SNP	Position	Gene/Var	A1/A2/AF1	MICROS (n = 1,218)		LBC1936 (n = 922)		LBC1921 (n = 443)		MARTHA (n = 986)a
					Beta/SE/Var%	p	Beta/SE/Var%	p	Beta/SE/Var%	p	p/Betab
13q34	rs561241c	112808035	F7/near 5′	T/C/0.71	0.035/0.003/11.76	7.80 × 10−27	0.040/0.004/8.78	2.75 × 10−19	0.059/0.007/12.12	1.56 × 10−15	7.05 × 10−20/-7.60
13q34	rs6046c	112821160	F7/cns	G/A/0.71	0.035/0.003/11.74	7.55 × 10−27	0.040/0.005/8.61	4.89 × 10−19	0.060/0.007/12.16	1.24 × 10−15	3.77 × 10−21/-7.99
20q11.2	rs2295888d	33186524	EDEM2/intr	A/G/0.85	−0.020/0.004/2.53	5.87 × 10−8	−0.018/0.005/1.60	7.77 × 10−5	−0.027/0.009/1.64	0.005	3.29 × 10−4/3.02
20q11.2	rs867186d	33228215	PROCR/cns	A/G/0.84	−0.020/0.004/2.50	9.98 × 10−8	−0.017/0.005/1.38	2.44 × 10−4	−0.024/0.009/1.37	9.6 × 10−3	3.46 × 10−4/2.97

Var, variant of the top SNP; A1, allele 1 (major allele); A2, allele 2 (minor allele); AF1, allele frequency for A1; Beta, change in international normalized ratio (INR) per copy of the A2 allele (minor allele); Var%, percentage of variance explained; cns, coding nonsynonymous; intr, intron.

^aBased on meta-analysis of MARTHA08 and MARTHA10.

^bThe Quick value, which is in inverse relationship to INR, was used in MARTHA.

^c,dSNPs labeled with similar symbols are in high linkage disequilibrium with each other. Imputation quality scores ≥ 0.97 for all SNPs.