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The effect of injury and minocycline treatment on spatial memory at different time points after mbTBI. Latency (seconds) to find and enter the escape box was measured for five consecutive days in the Barnes maze starting at (A) 10 days, and (B) 47 days after injury or sham. Data are presented as the average of the 2 daily trials per animal in each experimental group ±SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 for injured-vehicle vs. sham-vehicle rats.
