Time-dependent effect of pranlukast and montelukast on the arachidonic acid-induced CNS specimen (μl) (◇), counts of WBC (■) (A, B, C), and RCN9 cells (×) (D, E) are shown. Symbols represent the mean and the s.e.m. n = 6. Rats were pretreated with pranlukast (B, E), montelukast (C), or distilled water (A, D), and CNS specimen was collected every 30 min up to 8 h after arachidonic acid injection.