Table 1.

Typical biological and clinical characteristics of t-AML cases associated with alkylating agents and TOP2 poisons.

	TOP2 poison * associated(* such as etoposide, teniposide mitroxantrone, epirubicin)	Alkylating agent $ associated($ such as cyclophosphamide, melphalan, chlorambucil, and nitrosoureas)
Latency period	Short, <2 years	2–8 years
Chromosome abnormalities	Recurrent translocations especially involving MLL at 11q23 and t(15;17)(PML-RARA), t(8,21)(AML-ETO)	Deletions involving Chr 5 and 7
Complex Karyotype	Rare	Frequent
Preceded by myelodisplastic syndrome	Rare	Frequent
Age association	Younger	Older