Table 1.
TOP2 poison * associated(* such as etoposide, teniposide mitroxantrone, epirubicin) | Alkylating agent $ associated($ such as cyclophosphamide, melphalan, chlorambucil, and nitrosoureas) | |
---|---|---|
Latency period | Short, <2 years | 2–8 years |
Chromosome abnormalities | Recurrent translocations especially involving MLL at 11q23 and t(15;17)(PML-RARA), t(8,21)(AML-ETO) | Deletions involving Chr 5 and 7 |
Complex Karyotype | Rare | Frequent |
Preceded by myelodisplastic syndrome | Rare | Frequent |
Age association | Younger | Older |