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. Author manuscript; available in PMC: 2013 Jun 22.
Published in final edited form as: Chem Biol. 2012 Jun 22;19(6):721–730. doi: 10.1016/j.chembiol.2012.04.012

Figure 2. A prodrug of Immucillin-H 5’-phosphate (ImmHP) is converted to Immucillin-H by intracellular activities.

Figure 2

(a) The structure of ImmHP bis-pivalate prodrug 1. (b) Inhibition of cultured parasite growth by 1. (c) Extracellular purine analysis of metabolic labeling with [3H]hypoxanthine in uninfected erythrocytes treated with 25 µM 1. (d) The same experiment as in (c) but labeling with [3H]inosine. See also Table S1.