Skip to main content
. Author manuscript; available in PMC: 2013 Jun 22.
Published in final edited form as: Chem Biol. 2012 Jun 22;19(6):721–730. doi: 10.1016/j.chembiol.2012.04.012

Figure 3. Acyclic Immucillin phosphonate (AIP) prodrugs must avoid activation in the erythrocyte to reach parasite targets.

Figure 3

(a) The structure of AIP prodrug 4, the bispivalate compound prodrug of 2. (b) Inhibition of parasite growth inhibition by 4. (c) Extracellular purine analysis of metabolic labeling in uninfected erythrocytes treated with 100 µM 1 and [3H]hypoxanthine. (d) The same experimental design as in (c) but labeling with [3H]inosine. See also Table S2.