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. Author manuscript; available in PMC: 2013 Jun 22.
Published in final edited form as: Chem Biol. 2012 Jun 22;19(6):721–730. doi: 10.1016/j.chembiol.2012.04.012

Figure 5. Treatment of infected RBCs with AIP prodrugs inhibits PfHGXPRT.

Figure 5

Cells were metabolically labeled with [2,8-3H]hypoxanthine in the presence or absence of 10 µM 5 by incubation as in the methods. Purine incorporation was quantitated by HPLC of (a) uninfected RBCs, (b) erythrocyte-free parasites, (c) parasites isolated from infected erythrocytes, (d) extracellular purines from panel (c). The time (e) and concentration (f) dependence of label uptake were measured by liquid scintillation counting of spent media. The results are summarized in Table 1. See also Figure S1.