A. Advanced skin ulcers, eschars, and edema in the legs and feet. B. Epidermal necrosis and diffuse cutaneous inflammatory infiltration with leukocytoclastic vasculitis (arrows) and neuritis (dual arrows) (H & E, 35x). CDE. Invasion of the mycobacterium, as highlighted by red-colored bacilli, into the endothelia of a vein, arteriole, and medium artery respectively (Fite, 400x). E. Also endothelial proliferation. F. End stage occlusion of a medium artery (H & E, 100x).