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. 2012 Jun 20;10(6):1412–1421. doi: 10.3390/md10061412

Scheme 1.

Scheme 1

Synthesis of methanesulfonamide 10. Reagents and conditions: (a) K2CO3, acetone, BnBr, 0 °C, 98%; (b) phenyltriethylammonium tribromide, THF, 80%; (c) hexamethylenetetramine, chlorobenzene, then conc. HCl; (d) MsCl, Et3N, acetone/H2O 2:1, 60% over two steps.