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Dose-response curves show the antibacterial activities and reveal a structure-activity relationship for the chrysophaentins. Chrysophaentins A (1), D (4), and F (8), and fragment 12 were tested for their ability to inhibit the growth of Staphylococcus aureus UAMS-1 (panel A) and CA-MRSA USA300-LAC (panel B) in a microbroth dilution assay. Plots represent percentage bacterial growth as a function of compound concentration.
