Table 1.
Comparative inhibitory effects of 3ATA on the activity of MRP/ABCC proteins. The inhibitory ratios were obtained from data of Figures 3 and 4 by dividing the mean fluorescence intensity (MFI) of treated cells by the MFI of untreated cells. Results as expressed as mean ± SD. of data from 3 different experiments.
| Inhibition Ratio | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Treatment | B16F10 | Ma104 | A549 | 2008/MRP2 | HEK/MRP3 | 3T3/MRP4 |
| MK50 | 10.5 ± 1.7 | 5.4 ± 0.3 | 7.0 ± 1.1 | 1.8 ± 0.3 | 1.5 ± 0.2 | 3.7 ± 0.7 |
| MK100 | - | - | - | 3.6 ± 0.3 | 3.7 ± 0.1 | 6.1 ± 1.4 |
| PRO 1000 | - | - | - | - | 6.0 ± 0.1 | 7.7 ± 1.3 |
| 3ATA 6.25 | 5.6 ± 1.2 | 2.5 ± 0.1 | 2.9 ± 0.2 | 1.8 ± 0.2 | 1.2 ± 0.3 | 2.3 ± 0.4 |
| 3ATA 12.5 | 11.4 ± 1.3 | 3.2 ± 0.1 | 3.0 ± 0.3 | 2.7 ± 0.1 | 1.4 ± 0.3 | 3.1 ± 0.5 |
| 3ATA 25.0 | 20.9 ± 3.4 | 5.4 ± 0.2 | 4.0 ± 0.4 | 3.5 ± 0.2 | 1.7 ± 0.4 | 3.5 ± 0.3 |
- not determined.