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Diagram of the tetanus toxin molecule. The targeting and the translocation domains are located in the heavy-chain (HC), whereas the catalytic domain is located in the light-chain (LC) of the molecule. Its proteolytic activity is Zn2+-dependent, and heavy-metal chelators generate inactive apo-neurotoxins. The position of the cleavage of the tetanus-toxin molecule by papain is indicated. The digestion yields two fragments; one of them, fragment C, is approximately 50 kDa [29].
