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. 2012 Jun 7;13(6):6902–6923. doi: 10.3390/ijms13066902

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Histological analysis of control and atherosclerotic rabbits. Masson’s trichrome-stained histological slices illustrated the atherosclerotic plaques obtained in the vessel walls of a rabbit fed a high cholesterol diet and subjected to desendothelialization and angioplasty (A) and a control rabbit (normal diet, no surgery) (B). The aorta of the atherosclerotic animal showed complex plaque formation with intimal thickening and highly disorganized structures. Foam cells (FC) and collagen fibers (COL) (green) are interspersed. Necrotic cores (NC) and cholesterol (CH) were also present in the thick intima (I) of the atherosclerotic animal (A). In contrast, the control had a normal aorta with a single endothelial layer (SEL) covering a regular media (M) (B). L: lumen.