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. 2012 Jun 18;13(6):7508–7520. doi: 10.3390/ijms13067508

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The expression levels IL-6 in the three different groups at different time points (expressed as the mean (mg/L) ± SD). Peritoneal macrophages of the three groups are treated with LPS. In the C3H/HeN group, the concentration of IL-6 rose to a high level from 3 h to 6 h after LPS stimulation, reaching a higher level from 12 h to 24 h and finally returning to its original level after 48 h. The peak concentration appeared at 24 h after LPS stimulation. The other two groups did not have obvious changes throughout the course.