Figure 2. Pathologic examination with H&E staining and immunohistochemical analysis. (A) H&E stain showing tumor ulcerating though normal surface epithelium. (B) H&E stain at high magnification showing cytological malignant features such as prominent nuclei, vesicularly cleared chromatin, apoptotic figures, and numerous mitotic figures. (pathology photos by Lawrence Matthews M.D.,Ph.D.). Pathology revealed a pT4aN2bMX, LCNEC with diffuse cytoplasmic staining for synaptophysin (C), and 90% Ki-67 staining (D) (thick arrows). Normal tissue is seen at lower right (thin arrows).
