Table 2. Demonstration of hepatic parenchymal injury after chemotherapy for metastatic colorectal cancer.
| Reference | Agents used | Parenchymal injury after chemotherapy |
||
|---|---|---|---|---|
| Steatosis (%) | Steatohepatitis (%) | Sinusoidal obstruction-dilation (%) | ||
| Rubbia-Brandt et al. (67) |
5-FU/LV; IRI; OX |
20 |
NA |
32 |
| Karoui et al. (61) |
5-FU/LV; IRI; OX |
42 |
NA |
49 |
| Aloia et al. (73) |
5-FU/LV; OX |
13 |
NA |
23 |
| Pawlik et al. (74) |
5-FU/LV; IRI; OX |
18 |
2 |
5 |
| Scoggins et al. (2) | 5-FU/LV; IRI; OX | 17 | 15 | NA |
5-FU, 5-Fluorouracil; LV, leucovorin; IRI, irinotecan; OX, oxaliplatin.