Table 2. Toxicity observed during the trial.

Toxicity	Grade 1 [%]	Grade 2 [%]	Grade 3 [%]	Any Grade [%]
Diarrhea	9 [31]	6 [21]	2 [7]	17 [59]
Nausea	6 [21]	4 [14]	2 [7]	12 [41]
Vomiting	3 [10]	0	1 [3]	4 [14]
Fatigue	16 [55]	6 [21]	2 [7]	24 [83]
Neuropathy	6 [21]	0	0	6 [21]
Acneiform Rash	5 [17]	3 [10]	0	8 [28]
Hand Foot Syndrome	10 [34]	7 [24]	3 [10]	20 [69]
Mucositis	8 [28]	4 [14]	1 [3]	13 [45]
Small bowel obstruction	0	0	1 [3]	1 [3]
Anemia	14 [48]	3 [10]	0	17 [59]
Neutropenia	2 [7]	1 [3]	0	3 [10]
Thrombocytopenia	5 [17]	0	0	5 [17]
Hyperbilirubinemia	2 [7]	2 [7]	0	4 [14]
Ocular Surface conjunctivitis	0	0	1 [3]	1 [3]
Infection	0	0	1 [3]	1 [3]
Anorexia	6 [21]	0	1 [3]	7 [24]
Paronychia	1 [3]	2 [7]	0	3 [10]