Table 1.

Isoniazid Pharmacokinetics in 151 South African Infants Receiving Isoniazid for M. Tuberculosis Prophylaxis

	Week 0			Week 12			Week 84
Age (months) Median (Range)	3.34 (3.03–4.04)			6.23 (5.6–6.9)			22.97 (21.6–33.47)
Weight (kg) Median (Range)	5.8 (3.5–8.3)			7.5 (4.5–10.4)			11.6 (8.4–18.1)
NAT2 Genotype	Slow	Intermediate	Fast	Slow	Intermediate	Fast	Slow	Intermediate	Fast
CL/F (L/hr) Mean (SD)	1.4 (0.55)	2.9 (2.1)	3.5 (2.05)	1.85 (0.6)	2.86 (1.87)	4.3 (1.7)	3.9 (3.6)	4.7 (2.8)	6.1 (3.1)
CL/F (L/hr/kg) Mean (SD)	0.25 (0.12)	0.51 (0.34)	0.54 (0.32)	0.25 (0.09)	0.38 (0.25)	0.61 (0.24)	0.32 (0.3)	0.43 (0.22)	0.47 (0.23)
V/F (L) Mean (SD)	5.4 (1.36)	6.7 (2.9)	6.74 (2.87)	7.35 (1.8)	6.9 (2.63)	6.8 (1.8)	13.6 (8.8)	9.8 (4.0)	9.6 (4.2)
AUC0-24 (mg*hr/L) Mean (SD)	71.6 (25.8)	42.5 (19.3)	37.8 (20.5)	61.4 (20.7)	41.1 (15.4)	25.3 (9.8)	74.7 (49)	36 (15.5)	34 (16.3)
Cmax (mg/L) Mean (SD)	11.2 (3.36)	9.09 (3.29)	9.16 (3.88)	9.7 (2.54)	8.78 (2.67)	7.2 (2.2)	10.2 (5.3)	8.7 (3.1)	9.7 (3.7)
Tmax (hr) Mean (SD)	2.09 (0.09)	2.09 (0.08)	2.06 (0.28)	1.79 (0.11)	1.8 (0.09)	1.7 (0.1)	1.67 (0.11)	1.54 (0.08)	1.54 (0.1)
T1/2 (hr) Mean (SD)	2.83 (0.41)	1.77 (0.31)	1.45 (0.28)	2.8 (0.35)	1.8 (0.25)	1.15 (1.17)	3.14 (0.99)	1.5 (0.26)	1.2 (0.2)