Table 3.

INH Doses (mg/kg) needed to achieve Cmax ≥ 3 mg/L in 95% of infants and young children based on age. One thousand infants/young children were simulated at each age group. Slow, intermediate, and fast represent acetylation phenotype based on NAT2 genotype.

Age (month)	Mean Body Weight (kg)	INH daily dose (mg/kg)
		Slow	Intermediate	Fast
3	5.9	8.5	9.7	10.8
6	7.5	7.2	8.5	9.8
9	9.0	6.7	8.0	9.5
12	9.8	6.5	7.9	9.4
15	10.7	6.3	7.8	9.3
18	11.4	6.2	7.8	9.2
24	12.4	6.1	7.8	9.1
36	14.0	6.0	7.8	8.9
48	16.0	5.8	7.8	8.8
60	18.0	5.7	7.8	8.6