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. Author manuscript; available in PMC: 2012 Jul 16.
Published in final edited form as: J Alzheimers Dis. 2010;20(4):1243–1253. doi: 10.3233/JAD-2010-100210

Figure 5. BACE-1 and γ-secretase subunits are expressed in the retina and RPE cell layers.

Figure 5

BACE-1 (A), PS-1 (B), Aph-1 (C), Pen-2 (D), and nicastrin (NCT) (E) were analyzed in mouse (MUS), mouse retina (RET) and retinal pigment epithelium (RPE) cells. Transfected CHO cells (TF) were included as positive controls for all analyses and BACE-1 knockout (B-KO) mouse brain was also included for (A). BACE-1 and all γ-secretase subunits are expressed in the retina and RPE cells. Note that no knockout models exist for PS-1, Aph-1, Pen-2, and NCT.

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