Table 2.

Common Adverse Events

Adverse Event	Erlotinib				Erlotinib Plus Carboplatin and Paclitaxel				P*
	Grade 3		Grade 4		Grade 3		Grade 4
	No.	%	No.	%	No.	%	No.	%
Hematologic
Anemia	1	1	0	0	7	7	0	0	.0763
Febrile neutropenia	0	0	0	0	9	9	3	3	< .001
Neutropenia	0	0	0	0	24	24	17	17	< .001
Thrombocytopenia	0	0	0	0	1	1	4	4	.0659
Maximum	2	2	0	0	29	29	20	20	< .001
Nonhematologic
Allergic reaction (hypersensitivity)	0	0	0	0	4	4	0	0	.1291
Diarrhea	4	5	0	0	7	7	0	0	.7567
Fatigue	1	1	0	0	16	16	1	1	< .001
Nausea	1	1	0	0	7	7	0	0	.0763
Neuropathy (sensory)	0	0	0	0	6	6	0	0	.0338
Rash (acne/acneiform)	6	7	0	0	10	10	0	0	.6068
Vomiting	1	1	0	0	7	7	0	0	.0763
Maximum	18	22	2	2	39	39	13	13	< .001

NOTE. Comparisons are for grades 3 to 4 toxicities between erlotinib and erlotinib plus chemotherapy.

^*Fisher's exact test.