Table 2. Serious adverse events leading to treatment discontinuation in patients with a chronic hepatitis C virus infection in low- and middle-income countries, 1996–2011.
| Publication | Year | Country | No. of patients affected | Type of event (No. of patients affected) |
|---|---|---|---|---|
| Sood58 | 2002 | India | 3 | Psychiatric illness (2), hypotension (1) |
| Sood87 | 2006 | India | 3 | Agitated behaviour (1), liver decompensation (2) |
| Gupta71 | 2006 | India | 1 | Weakness (1) |
| Ahmed27 | 2011 | Pakistan | 14 | Thrombocytopenia, ascites, depression, arthralgia, weight loss, rash, fever, hair loss, epistaxisa |
| Khan46 | 2009 | Pakistan | 12 | Extreme weakness (6), severe depression (2), thyroid dysfunction (3), recurrent leukopenia (1) |
| Khokhar47 | 2002 | Pakistan | 2 | Myalgia (1), psychosis (1) |
| Khalid45 | 2009 | Pakistan | 1 | Severe depression (1) |
| Idrees42 | 2009 | Pakistan | 6 | Psychosis (6) |
| Butt75 | 2009 | Pakistan | 5 | Thrombocytopenia and neutropenia (2), refractory anaemia (2), ascites and hepatic encephalopathy (1) |
| Lerias de Almeida76 | 2009 | Brazil | 33 | Not stated |
| Lerias de Almeida90 | 2010 | Brazil | 7 | Not stated |
| Goncales78 | 2006 | Brazil | 10 | Depression (6), neutropenia (2), anaemia (1), low platelet count (1) |
| Narciso-Schiavon81 | 2010 | Brazil | 22 | Anaemia (2), thrombocytopenia (2), not stated (18) |
| Khattab91 | 2010 | Egypt | 4 | Not stated |
| El Makhzangy92 | 2009 | Egypt | 2 | Psychiatric disorder (1), haemolytic anaemia (1) |
| El-Zayadi22 | 1996 | Egypt | 8 | Not stated |
| El-Zayadi38 | 2005 | Egypt | 4 | Neutropenia (1), thyroid dysfunction (1), depression (1), neutropenia (1) |
| Yu111 | 2009 | China | 1 | Severe anaemia (1) |
| Gheorghe100 | 2007 | Romania | 11 | Severe psychiatric side-effects, severe haematological abnormalities, severe reactivation of previously controlled rheumatoid arthritis, cardiac deatha |
| Gheorghe99 | 2009 | Romania | 20 | Severe psychiatric side-effects (2), severe haematological abnormalities (9), occurrence or reactivation of auto-immune disease during antiviral therapy (7), cardiac death (1), not stated (1) |
| Gheorghe98 | 2005 | Romania | 10 | Severe haematological abnormalities, severe and protracted skin rash, acute cytomegalovirus hepatitisa |
| Gallegos-Orozco39 | 2005 | Mexico | 1 | Thyrotoxicosis (1) |
| Ridruejo106 | 2010 | Argentina | 18 | Not stated |
| Laufer104 | 2011 | Argentina | 2 | Thrombocytopenia (2) |
| Seow107 | 2005 | Malaysia | 1 | Excessive lethargy (1) |
| Pramoolsinsap50 | 1998 | Thailand | 3 | Thrombocytopenia (2), hyperthyroidism (1) |
| Kalantari44 | 2007 | Islamic Republic of Iran | 2 | Thrombocytopenia (1), major depression (1) |
| Petrenkiene49 | 2004 | Lithuania | 11 | Anaemia (1), thrombocytopenia (5), irritability (1), exacerbation of concomitant disease (1), not stated (3) |
| Belhadj95 | 2008 | Tunisia | 5 | Not stated |
| Sombie108 | 2011 | Burkina Faso | 2 | Not stated |
| Njoum105 | 2008 | Cameroon | 6 | Neutropenia, encephalitis, pancytopenia and thrombopeniaa |
a Detailed data were not available.