Table 2.
Multivariate Analysis for ECSS in Patients With LEC, SEER Data 1973-2007
| Characteristic | LEC (N = 26,848) |
|||||
|---|---|---|---|---|---|---|
| No. of Patients | EC Death | 5-Year ECSS ± SE (%) | HR | 95% CI* | P* | |
| Sex | < .001 | |||||
| Male | 19,957 | 12,081 | 24 ± 0.3 | 1 (reference) | ||
| Female | 6,891 | 4,275 | 28 ± 0.5 | 0.920 | 0.886 to 0.955 | |
| Age, years | < .001 | |||||
| 18-44 | 753 | 438 | 31 ± 1.5 | 0.774 | 0.701 to 0.855 | |
| 45-54 | 3,199 | 1,889 | 29 ± 0.8 | 0.807 | 0.764 to 0.852 | |
| 55-64 | 6,985 | 4,124 | 29 ± 0.5 | 0.794 | 0.760 to 0.831 | |
| 65-74 | 8,559 | 5,169 | 26 ± 0.5 | 0.848 | 0.813 to 0.883 | |
| ≥ 75 | 7,352 | 4,736 | 19 ± 0.5 | 1 (reference) | ||
| Race | .031 | |||||
| White | 20,222 | 12,043 | 26 ± 0.3 | 1 (reference) | ||
| African American | 3,905 | 2,624 | 22 ± 0.6 | 1.068 | 1.016 to 1.123 | |
| Asian | 1,272 | 836 | 23 ± 1.0 | 1.089 | 0.999 to 1.186 | |
| Hispanic | 1,341 | 780 | 26 ± 1.1 | 0.989 | 0.916 to 1.067 | |
| Native American | 108 | 73 | 22 ± 3.3 | 1.133 | 0.838 to 1.533 | |
| Histology | .003 | |||||
| Squamous | 13,935 | 9,185 | 24 ± 0.4 | 1 (reference) | ||
| Adenocarcinoma | 10,146 | 5,506 | 27 ± 0.5 | 0.927 | 0.889 to 0.968 | |
| Other | 2,767 | 1,665 | 24 ± 0.7 | 0.965 | 0.911 to 1.022 | |
Abbreviations: EC, esophageal cancer; ECSS, esophageal cancer–specific survival; LEC, locoregional esophageal cancer; HR, hazard ratio.
*
Based on ECSS in competing risks regression model, including all variables in the table and marital status, radiation sequence (no radiation/surgery, neoadjuvant radiation, adjuvant radiation, intraoperative radiation or unknown), stage (localized v regional), SEER registries, and year of diagnosis (1973-1982, 1983-1995, 1996-2007).