Table 1.
Variable | Overall |
Nonmetastatic Disease |
Advanced Metastatic Disease |
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---|---|---|---|---|---|---|---|---|---|---|
Before Adjuvant Therapy |
During Adjuvant Therapy |
After Adjuvant Therapy |
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No. | % | No. | % | No. | % | No. | % | No. | % | |
No. of patients | 248 | 100 | 20 | 8 | 46 | 19 | 130 | 52 | 52 | 21 |
Site | ||||||||||
Canada | 201 | 81 | 20 | 100 | 19 | 41 | 130 | 100 | 52 | 100 |
United States | 47 | 19 | — | 27 | 59 | — | — | |||
Age, years | ||||||||||
Mean | 55 | 49 | 53 | 57 | 55 | |||||
SD | 8 | 9 | 7 | 8 | 10 | |||||
Range | 30-74 | 30-61 | 40-70 | 31-73 | 36-74 | |||||
Weight, kg | ||||||||||
Mean | 76 | 78 | 75 | 77 | 70 | |||||
SD | 17 | 19 | 16 | 17 | 16 | |||||
BMI, kg/m2 | ||||||||||
Mean | 28 | 29 | 28 | 29 | 27 | |||||
SD | 6 | 7 | 6 | 6 | 5 | |||||
Range | 16-50 | 18-46 | 18-40 | 16-50 | 18-45 | |||||
KPS | ||||||||||
70 | 3 | 1 | — | — | — | 3 | 6 | |||
75 | 1 | < 1 | — | — | — | 1 | 2 | |||
80 | 6 | 2 | — | — | — | 6 | 12 | |||
90 | 43 | 17 | — | 13 | 28 | — | 30 | 60 | ||
100 | 193 | 78 | 20 | 100 | 33 | 72 | 130 | 100 | 10 | 20 |
Exercise behavior, min·wk−1 | ||||||||||
Mean | 222 | 135 | 199 | 270 | 172 | |||||
SD | 269 | 171 | 275 | 307 | 192 | |||||
Meeting ACSM guidelines* | 49 | 25 | 5 | 25 | 3 | 11 | 32 | 31 | 9 | 18 |
Time from primary diagnosis, months | ||||||||||
Mean | 21 | 1 | 7 | 27 | 25 | |||||
SD | 19 | 0.4 | 6 | 16 | 26 | |||||
Anatomic stage | ||||||||||
IA | 37 | 15 | 1 | 5 | 6 | 13 | 30 | 23 | — | |
IB | 37 | 15 | 4 | 20 | 3 | 7 | 30 | 23 | — | |
IIA | 52 | 21 | 12 | 60 | 18 | 39 | 22 | 17 | — | |
IIB | 43 | 17 | 2 | 10 | 11 | 24 | 30 | 23 | — | |
IIIA | 25 | 10 | 1 | 5 | 7 | 15 | 17 | 13 | — | |
IIIB | 1 | < 1 | — | 1 | 2 | — | — | |||
IIIC | 1 | < 1 | — | — | 1 | 1 | — | |||
IV | 51 | 21 | — | — | — | 52 | 100 | |||
Current cytotoxic therapy | NA | NA | ||||||||
Chemotherapy | 63 | 64 | 29 | 63 | 34 | 65 | ||||
Anthracycline-containing regimen | 43 | 68 | 29 | 100 | 14 | 41 | ||||
Trastuzumab | 29 | 30 | 17 | 37 | 12 | 23 | ||||
Radiation | 20 | 20 | 0 | 0 | 20 | 38 | ||||
Prior primary cytotoxic therapy | NA | NA | ||||||||
Chemotherapy | 128 | 70 | 96 | 74 | 32 | 62 | ||||
Anthracycline-containing regimen | 79 | 62 | 62 | 65 | 17 | 53 | ||||
Trastuzumab | 18 | 10 | 18 | 14 | 0 | 0 | ||||
Radiation | 127 | 70 | 102 | 78 | 25 | 48 |
Abbreviations: ACSM, American College of Sports Medicine; BMI, body mass index; KPS, Karnofsky performance status; NA, not applicable; SD, standard deviation.
ASCM guidelines defined as percentage of patients reporting ≥ 150 minutes · wk−1 of at least moderate and/or strenuous exercise.