Figure 6.

EEG delta, theta, and sigma power in NREMS and EEG delta and theta power in REMS during the first three sleep cycles: drug treatment conditions vs. placebo. Relative EEG delta (0.75-4.5 Hz), theta (4.75-8 Hz), and sigma (12-15 Hz) power (mean ± SEM; n = 12) correspond to the EXP/BLN night ratio of each drug treatment condition expressed as a percentage of the EXP/BLN night ratio of the PL condition in the 3 first cycles of nighttime sleep. This illustrates the difference between each drug treatment condition and the PL condition for specific frequency ranges. (A, B, C) Only in the 1^st cycle, the BAC-nap and SO-exp conditions showed increased relative delta and theta power and decreased relative sigma power compared to the PL condition, except for the BAC-exp condition which showed a significant increase of theta power in the 3^rd cycle (1-way mixed-model ANOVA by cycle for factor “treatment” P < 0.05; Dunnett-Hsu test [control = PL] P < 0.05: star). (D) In REMS, compared to the PL condition, relative delta power for the SO-exp condition increased during the 1^st cycle, while it increased for the BAC-exp condition during the 2^nd cycle and 3^rd cycle (one-way mixed-model ANOVA by cycle for factor “treatment” P < 0.05; Dunnett-Hsu test [control = PL] P < 0.05: star). (E) Relative theta power in REMS increased for the BAC-nap and SO-exp conditions during the 1^st cycle and increased for the BAC-exp condition during the 2^nd and 3^rd cycles (for statistical tests see D).