Figure 6. The effect of reduced caloric intake and methyl donor depletion on intestinal tumor formation.
A) and B) Total number of tumors per mouse in the small intestine (A) and colon (B) from MDS ad libitum (n=13), MDS pair-fed (n=12) and MDD (n=12) mice, respectively. C) Colon tumors were classified by size as indicated. Note that there were no large-sized (≥4mm) colon tumors in the MDD group. Each data point represents an individual mouse and the numbers indicate the mean value for each group. P-values are indicated in the Figure as determined using one-way analysis of variance followed by Bonferroni’s multiple comparison tests.