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. 2012 May 29;287(29):24092–24102. doi: 10.1074/jbc.M112.378240

FIGURE 7.

FIGURE 7.

LIF causes delayed recovery of bleachable rhodopsin through RPE-intrinsic gp130. Shown are spectrophotometric determinations of bleachable rhodopsin in fully dark-adapted gp130-Ret-cre WT and gp130-Ret-cre KO eyes (A) and of gp130-Ret&RPE-cre WT and gp130-Ret&RPE-cre DKO eyes (B) 5 days after intravitreal 3.0-μg LIF or PBS injections. Total rhodopsin levels were reduced by LIF in WT mice but not in mice in which gp130 was deleted in the retina. n = at least 3 for each group; **, p < 0.05 comparing LIF- to PBS-injected eyes. Error bars, S.E. LIF significantly reduced rhodopsin recovery in mice in which gp130 was only deleted in the retina (C). However, rhodopsin recovery was unaffected by LIF in mice in which gp130 was also deleted in the RPE (D). n = at least 3 for each group; ** p < 0.05 comparing LIF- to PBS-injected eyes by paired t test. Error bars, S.E.