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Docked UDP-GlcNAc (capped sticks) positioned for productive SN2 nucleophilic attack. Stabilization of the uridine, diphosphate, and sugar substituents of the cofactor involves H-bonding interactions with highly conserved residues of the UGT signature sequence (schematic). Bonding interactions are observed from Leu-352/Gln-354/Glu-377 to the uridine, Gln-372/Asn-373/Ser-374 to the diphosphate, and His-369/Gln-394 to the sugar moiety.
