FIGURE 2.
Passively induced EAE. The clinical score of naive WT mice after adoptive transfer of MOG(35–55)-stimulated LNC from WT (white circles) or p38α+/− (black circles) mice at 10 dpi. A single cell suspension of LNC from WT or p38α+/− mice at 10 dpi was stimulated in vitro with MOG(35–55) plus mouse IL-23. LNC with each genotype (5 × 107 cells/mouse) were adoptively transferred into naive WT mice intravenously, and mice were then injected with PTX on days 0 and 2 intravenously. The difference between the two groups was statistically significant (*, p < 0.05) as determined by Student's t test for unpaired values.