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. 2012 May 9;287(29):24330–24338. doi: 10.1074/jbc.M112.356303

FIGURE 5.

FIGURE 5.

Silencing of Mmp1a suppresses tumor growth and invasion of LLC1 lung cancer cells in mice. A, tumor growth following subcutaneous implantation of 200,000 shLuc (n = 10) or shMmp1a-2 (n = 21) transduced LLC1 cells in the abdominal fat pads of C57BL/6 female mice. B, mass of excised LLC1 tumors at the day 26 end point. C, Mmp1a mRNA expression in whole tumor homogenates (n = 6 per cohort) as determined by real-time PCR and expressed relative to Mmp1a mRNA levels in cultured shLuc LLC1 cells (1-fold). D, correlation between tumor size and Mmp1a mRNA expression of excised shMmp1a-2 tumors. E, invasion of shLuc or shMmp1a LLC1 transduced tumors into the abdominal musculature of mice as assessed by H&E-stained sections from subcutaneous tumors (10× magnification). Tumor/muscle interface is outlined in white. Values shown are mean ± S.E. *, p < 0.05; **, p < 0.01.