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Investigating the effect of introducing the S241P mutation within the core hinge of IgG4 WT of selected mutants. A, immunoblot analysis under non-reducing conditions with (+) or without (−) the S241P mutation. The membrane was probed with an anti-human FC antibody. B, the membrane was probed with an anti-human κ antibody. For both A and B, thick black lines indicate HC, thick gray lines indicate LC, and red lines indicate DSBs.
