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TLR9-mediated HLA-DR up-regulation in R892W B cells. Peripheral blood B cells enriched with anti-CD19 microbeads from the TLR9 R892W carrier (R892W) and from two representative normal healthy donors (ND6 and ND10) were stimulated with or without R848 or CpG 2006 for 48 h. NON, non-stimulated (media only). After harvest, the cells were stained for the expression of surface HLA-DR. The histograms display the mean fluorescence intensities.
