Table 1. The most relevant downregulated genes in PBMCs of M. bovis infected cattle.
| Process | Symbol | FC | adj.P.Val | Gene name |
| Immune response | ||||
| MRC1 | −3.303 | 2.564E-13 | Mannose receptor. C type 1 | |
| CXCR2 | −6.235 | 1.888E-11 | Interleukin 8 receptor. Beta | |
| RETN | −6.201 | 9.116E-19 | Resistin | |
| CSF1R | −4.440 | 5.873E-16 | Colony stimulating factor 1 receptor | |
| CCL8 | −4.272 | 6.349E-10 | Chemokine (C-C motif) ligand 8 | |
| CD14 | −4.140 | 1.562E-17 | CD14 molecule. | |
| FCAR | −4.129 | 6.639E-15 | Fc fragment of IgA. receptor | |
| LOC508666 | −3.963 | 1.659E-11 | C-C motif chemokine 23-like | |
| CSF3R | −3.567 | 1.974E-09 | Colony stimulating factor 3 receptor | |
| FCGR1A | −3.446 | 2.094E-15 | Fc fragment of IgG. high affinity Ia. receptor (CD64) | |
| NRP1 | −3.230 | 8.997E-10 | Neuropilin 1 | |
| IL1RN | −3.172 | 2.745E-18 | Interleukin 1 receptor antagonist | |
| CCL2 | −3.050 | 4.864E-18 | Chemokine (C-C motif) ligand 2 | |
| NFAM1 | −3.046 | 7.780E-13 | NFAT activating protein with ITAM motif 1/ | |
| PF4 | −3.038 | 9.815E-17 | Platelet factor 4 (CXC chemokine family) | |
| IL13RA1 | −2.963 | 1.893E-16 | Interleukin 13 receptor. alpha 1 | |
| CCR1 | −2.936 | 4.864E-17 | Chemokine (C-C motif) receptor 1 | |
| Inflamation and apoptosis | ||||
| TGM3 | −6.978 | Transglutaminase 3 | ||
| TGFBI | −4.198 | 4.277E-10 | TGF-β: Transforming growth factor beta | |
| TREM1 | −4.011 | 3.437E-17 | Triggering receptor expressed on myeloid cells | |
| PYCARD | −3.876 | 5.531E-16 | PYD and CARD domain | |
| IL1R1 | −3.866 | 8.108E-17 | PYD and CARD domain | |
| HAS2 | −3.663 | 2.858E-10 | Hyaluronan synthase 2 | |
| Metallopeptidases | ||||
| MMP9 | −5.390 | 5.689E-18 | Matrix metallopeptidase 9 | |
| ECM1 | −4.307 | 1.548E-16 | Extracellular matrix protein 1 | |
| MMP3 | −4.302 | 4.349E-15 | Matrix metallopeptidase 3 | |
| ADAM8 | −3.811 | 5.152E-17 | ADAM metallopeptidase domain 8 | |
| MMP19 | −3.599 | 1.075E-13 | Matrix metallopeptidase 19 | |
| ADAMTSL4 | −3.027 | 1.701E-16 | Metalloproteinase with thrombospondin motifs | |
| Endocytosis and cellular traffiking | ||||
| SASH1 | −4.934 | 1.167E-15 | SAM and SH3 domain | |
| SH3BP4 | −3.239 | 1.338E-13 | SH3-domain binding protein 4 | |
| VLDLR | −4.210 | 2.367E-17 | Very low density lipoprotein receptor | |
| LOC533894 | −4.154 | 3.107E-16 | Low density lipoprotein receptor-related protein 1 | |
| S100A9 | −3.967 | 1.992E-17 | S100 calcium binding protein A9 | |
| ARHGAP21 | −3.467 | 4.185E-16 | Rho GTPase activating protein 21 | |
| Others | ||||
| AREGB | −5.237 | 4.723E-13 | Amphiregulin B (epidermal growth factor family) | |
| PLAUR | −3.134 | 7.737E-17 | Plasminogen activator. urokinase receptor | |
FC: log2-fold change.